Sponsor message

Are you trying to break into aquaculture industry or already working in the field and looking to gain additional expertise for career development?

Mapping Immune Genes In Salmon

The Fish Site
by The Fish Site
4 October 2011, at 1:00am

NORWAY - Morten F. Lukacs' doctoral research at The Norwegian School of Veterinary Science has identified and mapped a group of immune genes that are the key to warding off infectious agents such as viruses and bacteria in salmon.

The Norwegian fish farming industry is continually growing and the production of Atlantic salmon is one of the country's flagships. One of the problems facing the industry is the threat from viral diseases and parasites, and it is difficult to find effective vaccines against these. But by increasing our knowledge of how salmon defend themselves against bacteria and viruses, we can develop better vaccines and breeding tools.

Salmon have an immune defence system designed to combat both bacterial and viral diseases, but it is still not clear exactly how it works.

One group of genes, called MHC, which can be found in everything from sharks to humans, is known to affect the development of diseases, such as diabetes in humans and viral infections in chickens. Earlier studies have also shown that in salmon, these genes affect the ability of the fish to withstand viruses and bacteria.

In order to discover whether these effects are due to MHC or to closely linked genes, Mr Lukacs carried out a characterisation of the areas of DNA where MHC genes are localised in Atlantic salmon.

Through his research, mr Lukacs has shown that most of the MHC class I genes are to be found in two duplicated areas which have undergone an extensive reshuffling, compared to those of the rainbow trout. These two species of fish are very closely related in their development, but they react differently to, for example, various kinds of viruses.

By mapping the genes, Mr Lukacs found 16 MHC genes, of which many may have new and interesting functions. The overall results of this doctoral research provide a solid platform for the understanding of MHC genes in salmon and for further studies of how these genes affect the fish's defence system against infectious agents.

Cand.scient. Morten F. Lukacs defended his doctoral thesis on 29 September 2011 at The Norwegian School of Veterinary Science. The thesis is entitled: "Characterisation of Major Histocompatibility Complex Class I and II Regions in Atlantic Salmon".

Sponsor message

UMass Sustainable Aquaculture Online Courses

Aquaculture is an increasingly important source of safe, nutritious, and sustainable seafood for people worldwide. Globally, aquaculture production must double by 2030 to keep pace with demand. These increases in demand for aquaculture products, food security considerations, and job creation have generated an increased need for skilled workers.

Discover how you can be part of this rapidly expanding industry.