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Diabetes Drugs Found to Cause Fish Intersex

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US - A medication commonly taken for Type II diabetes, which is being found in freshwater systems worldwide, has been shown to cause intersex in fish.

Intersex is condition that causes male fish to produce eggs.

A study by Professor Rebecca Klaper determined that the diabetes medicine metformin causes physical changes in male fish exposed to doses similar to the amount in wastewater effluent.

In addition to intersex conditions, the study showed fish exposed to metformin were smaller in size than those not exposed.

Because intersex fish are particularly prevalent downstream from wastewater treatment plants, many studies have investigated the effect of hormones from birth control pills, Ms Klaper said.

Initially, the results of her study seemed surprising since metformin is not a hormone and it targets blood sugar regulation.

However, Ms Klaper said it is also prescribed to women with a common hormonal disease called polycystic ovary syndrome.

The research in her lab indicates metformin could be a potential 'endocrine disruptor', a chemical that confuses the body's complicated hormonal messaging system, interrupting a range of normal activities, including reproduction.

Of the chemicals she has detected in water samples collected from Lake Michigan, Ms Klaper said that metformin stands out.

"It is the chemical we found in almost every sample and in the highest concentrations compared to other emerging contaminants - even higher than caffeine," she said.

The prevalence of the chemical in samples led Ms Klaper to investigate what effects the medication may have in the environment.

In a previous study, she exposed mature fish to metformin, and although there were no physical changes, she found the genes related to hormones for egg production were being expressed in males as well as females - an indication of endocrine disruption.

For the current study, the researchers monitored fish that had continuous exposure to metformin from birth to adulthood.

The next step is to determine the corresponding changes in the genome, which Ms Klaper is doing at UWM's Great Lakes Genomic Center.

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Further Reading

You can view the full report and author list by clicking here.