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Pollution Disturbs Norwegian Cod Hormone Balance

by the Fish Site Editor
25 March 2009, at 12:00am

NORWAY - New research shows that environmental pollutants in Store Lungegrdsvann in Bergen affect gene expression involved in detoxification mechanisms and hormone balance in Atlantic cod.

The research is part of the National Institute of Nutrition and Seafood Research' (NIFES) work to identify effects of environmental pollutants on fish health and seafood safety.

NIFES has studied the expression of genes in cod from the Store Lungegårdsvann, a seawater recipient in Bergen defined as relatively polluted, with considerable amounts of organic environmental pollutants present in the sediments. The cod from this location was compared with cod from the outer Hardanger Fjord, which is not considered to be a polluted area. The genes examined code for proteins known to respond to environmental pollutants often found in sewage and surface drainage water in urban areas. The project is part of ongoing research to determine how environmental pollutants affect fish health and seafood safety.

"The findings show that cod in the Store Lungegårdsvann are exposed to organic pollutants, and that they affect the expression of genes that are important for the detoxification mechanisms of the cod. In comparison to cod from the outer Hardanger Fjord, the CYP1A gene was up-regulated in male fish from the Store Lungegårdsvann, whereas it was down-regulated in the female cod. This also indicates that there are gender-specific differences in the regulation of CYP1A", says researcher Pål A. Olsvik in the Seafood Safety Programme at NIFES in Bergen.

The CYP1A gene is used as a biomarker for many organic environmental pollutants, including PCB and dioxin-like PCB, and plays an important role in the detoxification processes of animals. A biomarker is a change in a biological response that can be related to exposure to, or toxic effect of, an environmental chemical or chemicals.

"Studies from 2007 have shown that livers of cod obtained from Store Lungegårdsvann contain high levels of both PCB and dioxin-like PCB", says Olsvik.

Disturbed hormone balance?

Two out of five male fish caught in Store Lungegårdsvann showed considerable up-regulation of the three genes vitellogenin A (VtgA), VtgB and zona radiata 2 (ZP2) in the liver. These genes code for female egg yolk and egg shell proteins, commonly used as biomarkers for environmental estrogens in male fish.

This indicates that the male cod are affected by environmental estrogens. The estrogen inhibiting effect that has been found may be due to organic pollutants in the sediments and discharges from the sewage system. Store Lungegårdsvann is not a closed system, but has an opening into an adjoining fjord. As it is natural for the cod to move in and out of Store Lungegårdsvann, we can expect them to be affected to varying degrees. This may explain why elevated levels of these trancripts were only found only in two out of five males.

Estrogen inhibitors are substances which mimic natural estrogen in the body. Substances which mimic the body's natural hormones, and which can have the same effect, are called hormone inhibitors or hormone-disturbing substances.

the Fish Site Editor